The Cannabinoid Receptors

The Cannabinoid Receptors PDF
Author: Patricia H. Reggio
Publisher: Springer Science & Business Media
ISBN: 9781597455039
Size: 33.69 MB
Format: PDF, ePub
Category : Medical
Languages : un
Pages : 402

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The Cannabinoid Receptors

by Patricia H. Reggio, The Cannabinoid Receptors Books available in PDF, EPUB, Mobi Format. Download The Cannabinoid Receptors books, As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors TM series, this volume highlights its receptor with the most thorough, focused and essential information available. Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.



Biophysical Characterisation Of The Cannabinoid Receptor Interacting Protein Crip1a

Biophysical Characterisation of the Cannabinoid Receptor Interacting Protein CRIP1a PDF
Author: Louise Saul
Publisher:
ISBN:
Size: 68.52 MB
Format: PDF, ePub, Mobi
Category : Cannabinoids
Languages : un
Pages : 434

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Biophysical Characterisation Of The Cannabinoid Receptor Interacting Protein Crip1a

by Louise Saul, Biophysical Characterisation Of The Cannabinoid Receptor Interacting Protein Crip1a Books available in PDF, EPUB, Mobi Format. Download Biophysical Characterisation Of The Cannabinoid Receptor Interacting Protein Crip1a books, Endogenous cannabinoids, such as anandamide and 2-arachidonoyl-glycerol, are compounds naturally produced in the body that act as important signalling modulators, particularly, in the brain. Endocannabinoids bind to cannabinoid receptors (the CB1 and CB2 receptors), the same receptors to which the psychoactive tetrahydrocannabinol ingredient of Cannabis saliva derivatives bind. Endocannabinoids, together with their receptors, and the protein network involved in endocannabinoid synthesis, uptake, release and degradation constitute the endogenous cannabinoid system. The endogenous cannabinoid system is an emerging target in pharmacotherapy for the treatment of several diseases. In the context of a project aimed at studying important proteins of the ECS attention was focused on a 19kDa protein called Cannabinoid Receptor Interacting Protein la (CRIP la). CRIP la has been recently discovered, using a yeast-two-hybrid approach, as a binding partner of the CB1 receptor, but not the CB2 receptor. CRIP la has been suggested to bind to the C-terminal cytoplasmatic tail of the CB1 receptor and to reduce the CB1 receptor-mediated tonic inhibition of voltage-gated calcium currents. -- The CRIPla rat ortholog, RnCRIPla, was over-expressed in E. coli and purified to homogeneity. Single crystals of wild-type and selenomethionine-labelled RnCRIPla were grown using the microseeding technique and diffracted to high resolution using synchrotron radiation. The structure of RnCRlP1a was solved using the multiple anomalous diffraction technique at a resolution of 1.8 A. RnCRIPla is a domain-swapped dimer in the crystal. Its C-terminal region is in an extended (3-strand conformation, 'crossing over' to engage in a p-sheet symmetry-related molecule, thus resulting in the formation of a homodimer.



Characterisation Of Cannabinoid Receptors And Their Ligands In Isolated Smooth Muscle Preparations

Characterisation of Cannabinoid Receptors and Their Ligands in Isolated Smooth Muscle Preparations PDF
Author: Michael Gibson
Publisher:
ISBN:
Size: 55.30 MB
Format: PDF, Mobi
Category :
Languages : un
Pages :

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Characterisation Of Cannabinoid Receptors And Their Ligands In Isolated Smooth Muscle Preparations

by Michael Gibson, Characterisation Of Cannabinoid Receptors And Their Ligands In Isolated Smooth Muscle Preparations Books available in PDF, EPUB, Mobi Format. Download Characterisation Of Cannabinoid Receptors And Their Ligands In Isolated Smooth Muscle Preparations books,



Role Of The Endocannabinoid System In Islets Of Langerhans

Role of the Endocannabinoid System in Islets of Langerhans PDF
Author: Chen Li
Publisher:
ISBN:
Size: 20.24 MB
Format: PDF, ePub
Category : Cannabinoids
Languages : un
Pages : 458

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Role Of The Endocannabinoid System In Islets Of Langerhans

by Chen Li, Role Of The Endocannabinoid System In Islets Of Langerhans Books available in PDF, EPUB, Mobi Format. Download Role Of The Endocannabinoid System In Islets Of Langerhans books, The endocannabinoid system is composed of a family of locally produced endogenous cannabimimetic phospholipid derivatives, the cannabinoid receptors and enzymes for endocannabinoid biosynthesis and degradation. Two subtypes of cannabinoid receptor, CB1 and CB2, have been cloned, and their activation is coupled to inhibition of adenylate cyclase or alterations in Ca2+ levels. The well-known appetite-inducing effects of cannabis are mediated by activation of cannabinoid receptors and the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol (2-AG) are abundantly present in key brain areas participating in the regulation of food intake and satiety. CB1 receptors have been pharmacologically targeted to provide therapies for appetite suppression and there is considerable interest in the regulatory role of CB1 receptors in metabolic balance. Currently, there is little information available on the functional roles of CB2 receptors, nor on the related GPR55 receptor which has been identified as a novel cannabinoid receptor. Given the key roles of islet [3-cells in maintaining fuel homeostasis and the established involvement of the central endocannabinoid system in energy balance regulation, the experiments described in this thesis were designed to investigate the role of the cannabinoid receptors in islet function. -- Initial studies indicated that mRNAs encoding the classical (CB1, CB2) and novel (GPRS5) cannabinoid receptors were expressed by mouse insulinoma (MIN6) (3-cells, and by mouse and human islets as well as enzymes involved in endocannabinoid biosynthesis (DAG-lipase) and degradation (FAAH and MGL). Receptor proteins of both CB1 and CB2 receptors were also found to be present in mouse and human islets by western blotting.



Cannabinoids

Cannabinoids PDF
Author: Vincenzo Di Marzo
Publisher: Springer Science & Business Media
ISBN: 9780306482281
Size: 78.44 MB
Format: PDF
Category : Medical
Languages : un
Pages : 216

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Cannabinoids

by Vincenzo Di Marzo, Cannabinoids Books available in PDF, EPUB, Mobi Format. Download Cannabinoids books, The 21st century will witness the unprecedented marketing of therapeutic drugs developed from cannabinoids and the endocannabinoid system. Cannabinoids is a timely volume, which represents a comprehensive review of the most important issues in cannabinoid research as well as those of most likely therapeutic relevance. For the first time, the multi-faceted aspects of cannabinoid chemistry, biology and medicine are presented in one volume. Key topics of discussion: -major families of phytocannabinoids; -pharmacological activity of phytocannabinoids; -interactions of phytocannabinoids with their proposed molecular target; -components of the endocannabinoid system; -molecular mechanisms of the endocannabinoid system; -Physiological and pathological role of endocannabinoids; -industrial applications of studies on the cannabinoids; -therapeutic uses of agonists and antagonists of cannabinoids receptors. This book is a must for graduate and pre- and post-doctoral students in disciplines ranging from organic and natural product chemistry, pharmacology, biochemistry and medicine.



Marijuana And The Cannabinoids

Marijuana and the Cannabinoids PDF
Author: Mahmoud A. ElSohly
Publisher: Springer Science & Business Media
ISBN: 1592599478
Size: 38.47 MB
Format: PDF, Kindle
Category : Medical
Languages : un
Pages : 322

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Marijuana And The Cannabinoids

by Mahmoud A. ElSohly, Marijuana And The Cannabinoids Books available in PDF, EPUB, Mobi Format. Download Marijuana And The Cannabinoids books, Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.



Conformationally Constrained Analogs Of Org27569 As Allosteric Modulators Of Cb1 Cannabinoid Receptor

Conformationally Constrained Analogs of Org27569 as Allosteric Modulators of CB1 Cannabinoid Receptor PDF
Author: Siddhi Honavar
Publisher:
ISBN:
Size: 14.32 MB
Format: PDF, Mobi
Category : Allosteric regulation
Languages : un
Pages : 45

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Conformationally Constrained Analogs Of Org27569 As Allosteric Modulators Of Cb1 Cannabinoid Receptor

by Siddhi Honavar, Conformationally Constrained Analogs Of Org27569 As Allosteric Modulators Of Cb1 Cannabinoid Receptor Books available in PDF, EPUB, Mobi Format. Download Conformationally Constrained Analogs Of Org27569 As Allosteric Modulators Of Cb1 Cannabinoid Receptor books, The Cannabinoid receptors have become the focus of research due to their importance as targets for treating a number of disorders. These receptors which are a part of the G-protein coupled receptor (GPCR) superfamily are of two subtypes, CB1 receptors which are present abundantly in the brain and in small traces in the peripheral and adipose tissues and CB2 receptors which are predominantly found in the immune cells. The cannabinoid receptors were always known to show its function through the orthosteric ligand binding, but the discovery of allosteric site on the CB1 receptors, has opened up a whole new horizon for research. Three of Organon analogs displayed a noticeable allosterism at the CB1 receptors, wherein they were negative allosteric modulators of function but positive allosteric modulators of binding of orthosteric ligand at the CB1 receptor. The SAR around these three molecules has not been explored as much, and as all three almost shared the same phamacophoric properties, Org 27569 was selected as the lead compound. Org 27569 which is a negative allosteric modulator of CB1 receptor has been found to also show hypophagic effect independent of the presence of the CB1 receptor, and hence pointing towards the possibility of it's off target binding which is a major limitation in its further development as a drug. Exploring the SAR around Org 27569 would give a better insight into the molecules requirements for allosteric modulation at CB1 receptor. The Conformational restriction approach is adopted as a tool for molecular modification and design of the analogs. This projects aims at synthesizing conformationally constrained analogs of Org 27569 as GAT700 and GAT701, to explore the receptor binding and functional selectivity of the allosteric modulators at the CB1 cannabinoid receptor.



Endocannabinoids

EndoCANNABINOIDS PDF
Author: Mary E. Abood
Publisher: Springer Science & Business Media
ISBN: 1461446686
Size: 66.68 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : un
Pages : 288

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Endocannabinoids

by Mary E. Abood, Endocannabinoids Books available in PDF, EPUB, Mobi Format. Download Endocannabinoids books, Featuring research from many of the leading scientists in the field, this volume complements recent publications describing cannabinoids, focusing on the physiological and therapeutic characteristics of compounds that modulate CB1 and CB2 receptor function.



Cannabinoid Pharmacology

Cannabinoid Pharmacology PDF
Author:
Publisher: Academic Press
ISBN: 0128112336
Size: 46.48 MB
Format: PDF, Kindle
Category : Medical
Languages : un
Pages : 492

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Cannabinoid Pharmacology

by , Cannabinoid Pharmacology Books available in PDF, EPUB, Mobi Format. Download Cannabinoid Pharmacology books, Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation by cannabinoids. There is a broad coverage of the essential elements associated with the cannabinoid system. The Editors have sought to include authors who represent authoritative voices on these themes, but have not previously worked together to allow a fresh approach to the individual aspects covered. Presents reviews of recent breakthroughs in the cannabinoid system Features chapters from the best authors in the field Provides an essential resource for scientists, advanced undergraduate students through to established faculty members